Topo IIα (Q14) Antibody-抗体-抗体-生物在线
巴傲得生物科技有限公司
Topo IIα (Q14) Antibody

Topo IIα (Q14) Antibody

商家询价

产品名称: Topo IIα (Q14) Antibody

英文名称: Topo IIα (Q14) Antibody

产品编号: BS3010

产品价格: null

产品产地: USA

品牌商标: Bioworld

更新时间: null

使用范围: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

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DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination, and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIα and Topo IIβ. The 180 kDa isoform, Topo IIβ, and the 170 kDa isoform, Topo IIα, are largely homologous at their N-terminal three quarters, however, the C-terminal segments are considerably divergent, suggesting that these regions may mediate different cellular functions and account for the observed differential tissue expression patterns of the two isoforms.