IRAK4 polyclonal antibody
产品名称: IRAK4 polyclonal antibody
英文名称: IRAK4 polyclonal antibody
产品编号: PAB10251
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of IRAK4.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human IRAK4.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- No cross reactivity occurs against other IRAKs.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:5000-1:20000)
Western Blot (1:250-1:1000)
Immunohistochemistry (1:100-1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z.J Biol Chem. 1999 Jul 2;274(27):19403-10.
- 2.
- IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
Muzio M, Ni J, Feng P, Dixit VM.Science. 1997 Nov 28;278(5343):1612-5.
- 3.
- IRAK: a kinase associated with the interleukin-1 receptor.
Cao Z, Henzel WJ, Gao X.Science. 1996 Feb 23;271(5252):1128-31.
- Applications
- Western Blot (Cell lysate)
- Western blot using IRAK4 polyclonal antibody (Cat # PAB10251) shows detection of IRAK4 in HeLa whole cell lysate. The membrane was probed with the primary antibody dilutedto 1:1000 (lane 1), 1 : 500 (lane 2), and 1 : 250 (lane 3) respectively.
- Entrez GeneID:
- 51135
- Protein Accession#:
- NP_057207;Q9NWZ3
- Gene Name:
- IRAK4
- Gene Alias:
- IPD1,NY-REN-64,REN64
- Gene Description:
- interleukin-1 receptor-associated kinase 4
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq
- Other Designations:
- IRAK-4 mutated form 1,interleukin-1 receptor associated kinase 4
- Related Disease
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Birth Weight
- Bronchiolitis, Viral
- Cardiovascular Diseases
- Chronic Disease
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Glioblastoma
- Glioma
- HIV Infections
- Hypersensitivity
- Infant, Premature, Diseases