FITC标记的βA3/A1-crystallin蛋白抗体
产品名称： FITC标记的βA3/A1-crystallin蛋白抗体
英文名称： Anti-beta Crystallin A3/FITC
产品编号： HZ-12859R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-beta Crystallin A3/FITC Conjugated antibody
FITC标记的βA3/A1-crystallin蛋白抗体
| 英文名称 | Anti-beta Crystallin A3/FITC |
| 中文名称 | FITC标记的βA3/A1-crystallin蛋白抗体 |
| 别 名 | Beta crystallin A3 isoform A1 Delta4 form; Beta crystallin A3; Beta crystallin A3 isoform A1 Delta7 form; Beta crystallin A3 isoform A1 Delta8 form; Beta-crystallin A3; CRBA1_HUMAN; CRYB1; CRYBA1; Crystallin beta A1; Crystallin beta A3; Delta8 form; Eye lens structural protein; isoform A1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human beta Crystallin A3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into a, b, and g families, and the b- and g-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. b-crystallins constitute the major lens structural proteins. They associate into dimers, tetramers, and higher order aggregates. The b-crystallin subfamily is composed of several gene products, including bA1-, bA2-, bA3-, bA4-, bB1-, bB2- and bB3-crystallin. The bA1- and bA3-crystallin proteins are encoded by a single mRNA. They differ by only 17 amino acids, and bA1-crystallin is generated by use of an alternate translation initiation site. The genes for bA4-, bB1-, bB2- and bB3-crystallin are clustered on human chromosome 22q11, while the genes for bA3/A1- and bA2-crystallin map to human chromosomes 17q11 and 2q34, respectively. Function: Crystallins are the dominant structural components of the vertebrate eye lens. Subunit: Homo/heterodimer, or complexes of higher-order. Thestructure of beta-crystallin oligomers seems to be stabilizedthrough interactions between the N-terminal arms (By similarity). Post-translational modifications: Specific cleavages in the N-terminal arm occur during lens maturation and give rise to several truncated forms. Cleavages do not seem to have adverse effects on solubility. S-methylation and glutathionylation occur in normal young lenses and do not seem to be detrimental. Isoform A1 initiator methionine is removed. The new N-terminal amino acid is then N-acetylated. DISEASE: Defects in CRYBA1 are the cause of cataract congenital zonular with sutural opacities (CCZS) [MIM:600881]. A form of zonular cataract. Zonular or lamellar cataracts are concentric opacities, broad or narrow, usually consisting of powdery white dots affecting one lamella or zonule of an otherwise clear lens. Similarity: Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains. Database links: UniProtKB/Swiss-Prot: P05813.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
晶体是脊椎动物眼睛晶状体的主要蛋白质，它们维持晶状体的透明度和折射率。晶状体被分为A、B和G族，B和G晶状体也包括超家族。结晶蛋白通常包含七个独特的蛋白质区域，包括四个同源基序，一个连接肽，以及N端和C端延伸。B晶状体是主要的晶状体结构蛋白。它们与二聚体、四聚体和高阶聚集体缔合。B-晶状体蛋白亚家族由多个基因产物组成，包括Ba1--、Ba2-、Ba3-、Ba4-、BB1-、BB2--和BB3晶状体蛋白。BA1和BA3晶状体蛋白由单个mRNA编码。它们仅相差17个氨基酸，而BA1晶状体蛋白通过使用另一个翻译起始位点而生成。bA4-、bB1-、bB2-和bB3-晶体蛋白基因簇集于人类染色体22q11上，而bA3/A1-和bA2-晶体蛋白基因分别定位于人类染色体17q11和2q34。