FITC标记的CD174抗体
产品名称： FITC标记的CD174抗体
英文名称： Anti-CD174/FUT3/FITC
产品编号： HZ-10184R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CD174/FUT3/FITC Conjugated antibody
FITC标记的CD174抗体
| 英文名称 | Anti-CD174/FUT3/FITC |
| 中文名称 | FITC标记的CD174抗体 |
| 别 名 | FUT3; FT3B; LE; Blood group Lewis alpha-4-fucosyltransferase; Fucosyltransferase 3; Fucosyltransferase III; Lewis FT; FucT-III; FUT3_HUMAN; Galactoside 3(4)-L-fucosyltransferase; Fucosyltransferase III; CD174; FT3B; Les. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞类型标志物 跨膜蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FUT3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. Subcellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Tissue Specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver. Similarity: Belongs to the glycosyltransferase 10 family. Database links: Entrez Gene: 2525 Human Omim: 111100 Human SwissProt: P21217 Human Unigene: 169238 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Lewis组织血型系统包括一组岩藻糖基化的糖鞘脂，由外分泌上皮细胞合成并在体液中循环。鞘糖脂在胚胎发生、组织分化、肿瘤转移、炎症和细菌粘附中起作用。它们被二次吸收到红细胞中，从而引起其刘易斯表型。该基因是岩藻糖基转移酶家族的成员，该家族在Lewis抗原生物合成的最后一步中催化岩藻糖与前体多糖的加成。它编码α（1,3）-岩藻糖基转移酶和α（1,4）-岩藻糖基转移酶活性的酶。该基因的突变是大多数Lewis抗原阴性表型的原因。已发现多个交替剪接变异体，编码相同的蛋白质。[ RefSeq，JUL 2008 ]提供。