FGFR1 polyclonal antibody
产品名称： FGFR1 polyclonal antibody
英文名称： FGFR1 polyclonal antibody
产品编号： PAB6742
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of FGFR1.
- Immunogen:
- A synthetic peptide corresponding to human FGFR1.
- Sequence:
- CLPRHPAQLANGGLKR
- Host:
- Goat
- Theoretical MW (kDa):
- 91.9, 91.6, 82.2, 81
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize 5 (out of nine reported) isoforms (as represented by NP_000595, NP_056934, NP_075593, NP_075594, NP_075599).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Expression and function of placenta growth factor: implications for abnormal placentation.
Torry DS, Mukherjea D, Arroyo J, Torry RJ.J Soc Gynecol Investig. 2003 May;10(4):178-88.
- Applications
- Western Blot (Tissue lysate)
- FGFR1 polyclonal antibody (Cat # PAB6742) (0.3 ug/mL) staining of human breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
- Entrez GeneID:
- 2260
- Protein Accession#:
- NP_000595;NP_056934;NP_075593;NP_075594;NP_075599
- Gene Name:
- FGFR1
- Gene Alias:
- BFGFR,CD331,CEK,FGFBR,FLG,FLJ99988,FLT2,HBGFR,KAL2,N-SAM
- Gene Description:
- fibroblast growth factor receptor 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
- Other Designations:
- FMS-like tyrosine kinase 2,OTTHUMP00000190874,OTTHUMP00000190878,OTTHUMP00000190879,OTTHUMP00000190881,basic fibroblast growth factor receptor 1,fms-related tyrosine kinase 2,fms-related tyrosine kinase-2,heparin-binding growth factor receptor,hydroxyaryl
- Interactome
- Related Disease
- Abnormalities, Multiple
- Acrocephalosyndactylia
- Alzheimer Disease
- Alzheimer disease
- Amenorrhea
- Anodontia
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Cardiovascular Diseases
- Chromosome Aberrations
- Chromosome Disorders
- Cleft Lip
- Cleft Palate
- Craniofacial Dysostosis
- Craniosynostoses
- Diabetes Complications
- Fractures, Bone
- Genetic Diseases, Inborn