EIF4EBP1 polyclonal antibody
产品名称： EIF4EBP1 polyclonal antibody
英文名称： EIF4EBP1 polyclonal antibody
产品编号： PAB18142
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EIF4EBP1.
- Immunogen:
- A synthetic peptide corresponding to human EIF4EBP1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to EIF4EBP1.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
Liu G, Zhang Y, Bode AM, Ma WY, Dong Z.J Biol Chem. 2002 Mar 15;277(11):8810-6. Epub 2002 Jan 2.
- 2.
- Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver.
Jiang YP, Ballou LM, Lin RZ.J Biol Chem. 2001 Apr 6;276(14):10943-51. Epub 2001 Jan 25.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from Jurkat cells, treated with Insulin (0.01 U/mL, 15 mins), using EIF4EBP1 polyclonal antibody (Cat # PAB18142).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 1978
- Protein Accession#:
- Q13541
- Gene Name:
- EIF4EBP1
- Gene Alias:
- 4E-BP1,4EBP1,BP-1,MGC4316,PHAS-I
- Gene Description:
- eukaryotic translation initiation factor 4E binding protein 1
- Omim ID:
- 602223
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
- Other Designations:
- eIF4E-binding protein 1,phosphorylated heat- and acid-stable protein regulated by insulin 1
- Interactome
