FCGR3A monoclonal antibody, clone LNK16 (FITC)
产品名称： FCGR3A monoclonal antibody, clone LNK16 (FITC)
英文名称： FCGR3A monoclonal antibody, clone LNK16 (FITC)
产品编号： MAB4360
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native FCGR3A.
- Immunogen:
- Native purified FCGR3A from normal human peripheral blood granulocytes.
- Host:
- Mouse
- Reactivity:
- Human, Non-Human Primates
- Specificity:
- This antibody reacts with CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA; 50-65 KDa; expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB; 48 KDa; mainly expressed on neutrophils).
- Form:
- Liquid
- Conjugation:
- FITC
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16.
Boyle JJ.Clin Exp Immunol. 2004 Sep;137(3):529-37.
- 2.
- IgE-mediated activation of NK cells through Fc gamma RIII.
Arase N, Arase H, Hirano S, Yokosuka T, Sakurai D, Saito T.J Immunol. 2003 Mar 15;170(6):3054-8.
- 3.
- The binding epitopes of human CD16 (Fc gamma RIII) monoclonal antibodies. Implications for ligand binding.
Tamm A, Schmidt RE.J Immunol. 1996 Aug 15;157(4):1576-81.
- Application Image
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 2214
- Gene Name:
- FCGR3A
- Gene Alias:
- CD16,CD16A,FCG3,FCGR3,FCGRIII,FCR-10,FCRIII,FCRIIIA,IGFR3
- Gene Description:
- Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- Fc fragment of IgG, low affinity III, receptor for (CD16),Fc fragment of IgG, low affinity IIIa, receptor for (CD16),Fc gamma receptor III-A,Fc-gamma RIII-alpha,Fc-gamma RIIIa,Fc-gamma receptor III-2 (CD 16),Fc-gamma receptor IIIb (CD16),FcgammaRIIIA,OTTH
- Interactome
- Related Disease
- Acute Disease
- Addison Disease
- Aggressive Periodontitis
- Agranulocytosis
- Alveolar Bone Loss
- Anemia, Sickle Cell
- Anemia, sickle cell
- Anti-Glomerular Basement Membrane Disease
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Autoimmune Diseases
- Behcet Syndrome
- Breast cancer
- Breast Neoplasms
- Candidiasis
- Carcinoma, Squamous Cell